Needle-free Continuous glucose monitoring

Glucose monitoring is fundamental to managing diabetes, which affects approximately 14% of the global adult population. However, the inconvenience and high cost of current invasive solutions limit accessibility. To address these challenges, we have developed Talisman, a needle-free wearable continuous glucose monitor (CGM) based on magnetohydrodynamics (MHD). Talisman, designed for large-scale manufacturing, comprises a reusable, rechargeable device, replaceable sensors, and a smartphone app. In a study involving 100 participants (10 healthy individuals and 90 with type 2 diabetes), Talisman achieved a Mean Absolute Relative Difference (MARD) of 13%, demonstrating strong correlation with reference blood glucose measurements. Safety assessments, including dermatological examinations and measurements of transepidermal water loss, revealed no evidence of adverse skin reactions. By providing an accurate, cost-effective, sustainable, and needle-free glucose monitoring solution, Talisman has the potential to significantly enhance diabetes management and expand access to glucose monitoring globally.