Organic Photovoltaics (OPV) is a solar energy technology made from earth-abundant materials and is mass-producible at low cost using Roll-to-Roll (R2R) printing methods. OPV is capable of efficiently harvesting light energy in both indoor and outdoor environments while being lightweight, flexible, and partially transparent, enabling a wide range of applications. The light-harvesting layer, or “active layer” of an OPV device is critically important and consists of a blend of two or more organic semiconductors. Modern active layer materials have achieved power conversion efficiencies of ~20%, demonstrating the potential of this technology for widespread use. For mass production, the synthesis of active layer materials should be scalable, sustainable, and Repeatable. This talk will cover advancements in the scale-up production of our Generation 1 (G1) active layer materials for use in large-format OPV panels. The importance of low batch-to-batch variability for the mass production of organic semiconductors will be discussed, along with preliminary results in printed devices.